🧪 Active Ingredient Profile

Indoxacarb — Why Advion Cockroach Gel Works So Well

Oxadiazine · CAS 144171-61-9

Indoxacarb is the active ingredient in Advion cockroach gel bait — considered the most effective single product for German cockroach control. Its proinsecticide mechanism makes it uniquely selective: insects activate it; mammals don't.

Mode of Action Proinsecticide — converted by insect enzymes to the active DCJW metabolite, which blocks sodium channels; mammals lack the enzyme, making it highly selective to insects
⚖️ Educational use only. Always read and follow the full product label — the label is the law under FIFRA. Full disclaimer → | ⚗️ Mixing Calculator →

📋 Key Facts

Class
Oxadiazine
Signal Word
Caution
Unique Property
Proinsecticide — activated BY insects, not on contact
Selectivity
Insects convert to active form; mammals lack the enzyme
Key Product
Advion Cockroach Gel Bait — #1 professional cockroach bait
Resistance
Low resistance documented vs most gel baits
Residual
30+ days as gel bait

🎯 Primary Uses

Indoxacarb is used almost exclusively as a gel bait for cockroaches and ants. Advion Cockroach Gel is the flagship product — widely considered the most effective cockroach bait available for German cockroach control. Advion Ant Gel contains the same AI. The proinsecticide mechanism provides inherent selectivity not seen with other insecticide classes.

🛡️ Safety Summary

Among the safest insecticides for mammals due to the proinsecticide mechanism — mammals lack the enzyme that activates indoxacarb. Very low acute and chronic toxicity in mammalian studies. Gel bait application minimizes exposure risk further — tiny amounts applied in cracks and voids.

Example
0.5 oz
per gallon
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🔬 Resistance Status

Resistance to indoxacarb is less common than to fipronil baits in cockroach populations — possibly due to the proinsecticide activation step creating additional resistance barriers. Currently considered the most resistance-resistant gel bait active ingredient. Rotate with fipronil and hydramethylnon baits to maintain efficacy.

🏷️ Common Products

Advion Cockroach Gel BaitAdvion Ant GelAdvion Evolution Cockroach BaitArilon Insecticide

🐛 Pests This Treats — Learn More

Click any pest to view its full identification guide, biology, and treatment options.

🐛 Ants → 🐛 Cockroaches → 🐛 Scales → 🐛 Ticks →

🌿 Environmental & Ecological Impact

🐝 Bees / PollinatorsLOW
🐟 Fish / Aquatic LifeLOW
🐦 BirdsLOW
🐕 Mammals / PetsLOW
🦐 Aquatic InvertebratesMODERATE
💡 Reduced-risk pesticide. Activated inside the insect — low risk to non-target organisms. Relatively bee-safe.

⏱️ Residual & Re-entry Timeline

🔹
Apply
Follow label mixing and application rates
🔸
Re-entry: 2–4 hours
Keep people and pets out of treated area
🟢
Effective period: 14–30 days
Active residual — killing or repelling target pests
🔄
Reapply
Re-treat when pest activity returns or residual expires

🔄 Alternatives & Related Products

Same chemical class or different approaches to the same pests.

↔️
Pyrethrin
Different approach: Botanical Pyrethrin
↔️
Boric Acid
Different approach: Inorganic

❓ Frequently Asked Questions

Q: Is indoxacarb safe for pets?
Follow the product label. Keep pets out of treated areas until completely dried (2–4 hours for sprays). Once dry, treated surfaces pose minimal risk to dogs and cats.
Q: Can I use indoxacarb indoors?
Yes — Indoxacarb is commonly used indoors in bait and dust formulations. Apply in cracks, crevices, and voids away from food surfaces.
Q: How long does indoxacarb last after application?
Residual varies by formulation, surface type, weather, and UV exposure. Indoor applications last longer than outdoor. Check the product label for re-application intervals.
Q: What should I do if exposed?
Remove contaminated clothing, wash skin with soap and water. For eye contact, rinse 15–20 minutes. For ingestion or severe symptoms, call Poison Control (1-800-222-1222). Have the product label available.

📋 Safety Data Sheet (SDS)

📋

Indoxacarb — Safety Data Sheet

View the official SDS document for this product directly on the CDMS label database.

Indoxacarb Safety Data Sheet page 1
📄 Indoxacarb — Safety Data Sheet · View the complete SDS document above or download below
📚 Sources: EPA Pesticide Labels · NPIC Pesticide Info
Published: Jan 1, 2025 · Updated: Apr 7, 2026
🔮
Reviewed by Derek GiordanoContent reviewed by a licensed pest management professional and cross-referenced against EPA, university extension, and manufacturer technical data. Last reviewed: April 2026.