πŸ§ͺ Active Ingredient Profile

Spinosad Biopesticide Profile

Naturalyte / Macrocyclic Lactone

Spinosad is derived from a naturally occurring soil bacterium (Saccharopolyspora spinosa). Despite being a 'natural' product, it's remarkably effective β€” used in organic farming, veterinary flea treatments, and fire ant control.

πŸ§ͺ
CAS Number
168316-95-8 (spinosyn A)
Mode of Action
Activates nicotinic acetylcholine and GABA receptors β€” distinct dual mode of action provides unique efficacy spectrum with no cross-resistance to pyrethroids or organophosphates
βš–οΈ Educational use only. Always read and follow the full product label β€” the label is the law under FIFRA. Full disclaimer β†’ | βš—οΈ Mixing Calculator β†’

πŸ“‹ Key Facts at a Glance

Chemical Class
Naturalyte (biological origin)
Signal Word
Caution
OMRI Listed
Yes β€” approved for certified organic production
Mode of Action
Dual β€” nicotinic acetylcholine + GABA (unique β€” no cross-resistance)
Bee Toxicity
Moderate when wet; low once dried β€” apply in evening when bees aren't foraging
Aquatic Toxicity
Low
Residual Duration
7-14 days outdoor; longer indoors

🎯 Primary Uses in Pest Control

Spinosad is used for: fire ant bait (Fertilome Come and Get It, Monterey Garden Insect Spray), caterpillar/worm control in gardens, veterinary flea treatments (Comfortis, Capstar for dogs; Natroba for human lice), thrips control, and leafminer treatment. It's particularly valued where resistance to conventional insecticides is a problem.

πŸ›‘οΈ Safety Summary

Among the safest insecticides for mammals, birds, and most non-target invertebrates. Well-tolerated by dogs and cats at veterinary use rates. Approved for use around food crops close to harvest. Primary non-target concern: moderately toxic to bees when wet β€” apply in evening after bees have returned to hives.

Example
0.5 oz
per gallon
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πŸ”¬ Resistance Status

Limited resistance documented β€” the dual mode of action slows resistance development. Some resistance in diamondback moth (agricultural) after extended use. In structural pest control, resistance is not a significant concern.

🏷️ Common Products Containing Spinosad

Comfortis (fleas)Capstar (fleas)Conserve SCMonterey Garden Insect SprayFertilome Come and Get ItSpinosad Fire Ant Bait

πŸ› Pests This Treats β€” Learn More

Click any pest to view its full identification guide, biology, and treatment options.

πŸ› Ants β†’ πŸ› Caterpillar β†’ πŸ› Fire Ant β†’ πŸ› Fleas β†’ πŸ› Scales β†’ πŸ› Thrips β†’ πŸ› Ticks β†’

🌿 Environmental & Ecological Impact

🐝 Bees / PollinatorsHIGH
🐟 Fish / Aquatic LifeLOW
🐦 BirdsLOW
πŸ• Mammals / PetsLOW
🦐 Aquatic InvertebratesLOW
πŸ’‘ Low toxicity to most non-target organisms. Toxic to bees when wet β€” apply in evening. OMRI organic listed.

⏱️ Residual & Re-entry Timeline

πŸ”Ή
Apply
Follow label mixing and application rates
πŸ”Έ
Re-entry: 4 hours
Keep people and pets out of treated area
🟒
Effective period: 7-14 days
Active residual β€” killing or repelling target pests
πŸ”„
Reapply
Re-treat when pest activity returns or residual expires

πŸ”„ Alternatives & Related Products

Same chemical class or different approaches to the same pests.

↔️
Pyrethrin
Different approach: Botanical Pyrethrin
↔️
Boric Acid
Different approach: Inorganic

❓ Frequently Asked Questions

Q: Is spinosad safe for pets?
Follow the product label. Keep pets out of treated areas until completely dried (2–4 hours for sprays). Once dry, treated surfaces pose minimal risk to dogs and cats.
Q: Can I use spinosad indoors?
Check the specific product label β€” formulations vary. Baits and dusts often have indoor labeling; concentrates and granulars are typically outdoor.
Q: How long does spinosad last after application?
Residual varies by formulation, surface type, weather, and UV exposure. Indoor applications last longer than outdoor. Check the product label for re-application intervals.
Q: What should I do if exposed?
Remove contaminated clothing, wash skin with soap and water. For eye contact, rinse 15–20 minutes. For ingestion or severe symptoms, call Poison Control (1-800-222-1222). Have the product label available.

πŸ“‹ Safety Data Sheet (SDS)

πŸ“‹

Spinosad β€” Safety Data Sheet

View the official SDS document for this product directly on the CDMS label database.

Spinosad Safety Data Sheet page 1
πŸ“„ Spinosad β€” Safety Data Sheet Β· View the complete SDS document above or download below
πŸ“š Sources: EPA Pesticide Labels Β· NPIC Pesticide Info
Published: Jan 1, 2025 Β· Updated: Apr 7, 2026
🔮
Reviewed by Derek GiordanoContent reviewed by a licensed pest management professional and cross-referenced against EPA, university extension, and manufacturer technical data. Last reviewed: April 2026.