🧪 Active Ingredient Profile

Cyantraniliprole

Diamide Insecticide (Ryanodine Receptor Modulator)

Cyantraniliprole represents the newest generation of insecticides — diamides that target insect muscle contraction through a completely novel mechanism. Extremely effective against caterpillars, whiteflies, and many sucking insects while being one of the safest insecticides ever created for bees and beneficial insects.

🧪
Classification
Diamide Insecticide (Ryanodine Receptor Modulator)
Signal Word
Caution
Mode of Action
Ryanodine receptor modulator: locks insect muscles in permanent contraction → paralysis → death
⚖️ Educational use only. Always read and follow the full product label — the label is the law under FIFRA. Full disclaimer → | ⚗️ Mixing Calculator →

🎯 Target Pests

Caterpillars (all Lepidoptera), whiteflies, aphids, thrips, leafminers, psyllids, flea beetles, Colorado potato beetle, Asian citrus psyllid, diamondback moth. Broad spectrum against chewing and sucking insects while maintaining excellent pollinator safety. Used in turf for white grubs.

🏷️ Products & Brand Names

Mainspring GNL (professional ornamental), Acelepryn (professional turf — grub control), Ference (professional), Besiege (agricultural, combined with lambda-cyhalothrin), Exirel (agricultural), Verimark (drip application). Limited homeowner products currently — primarily professional market.

⚠️ Safety & Precautions

Exceptionally low mammalian toxicity — one of the safest synthetic insecticides ever developed. Reduced risk designation from EPA. Very low toxicity to bees at labeled rates (a key advantage over neonicotinoids). Low toxicity to fish and birds.

Pollinator safety: Cyantraniliprole is one of the first highly effective insecticides that can be applied to flowering crops with minimal bee risk. This has made it transformational for IPM programs that need insect control without harming pollinators.
Example
0.5 oz
per gallon
⚗️ Mixing Calculator
Enter your sprayer size and target rate — get the exact amount to pour. Backpack, hand sprayer, hose-end, or skid unit.
Open Calculator →

💡 Pro Tips

Why this matters: Diamide insecticides like cyantraniliprole are filling the gap left by neonicotinoid restrictions. They provide similar effectiveness against key pests but with dramatically better pollinator safety profiles.

For grubs (turf): Acelepryn (cyantraniliprole) is increasingly replacing Merit (imidacloprid) for preventive grub control in lawns. Apply in April-May before grubs are present. Provides season-long control with a single application and minimal environmental impact.

Mode of action: Diamides activate ryanodine receptors in insect muscles, causing uncontrolled calcium release. The muscles lock in contraction — the insect becomes paralyzed and dies. Mammalian ryanodine receptors are structurally different enough that the compound has very low cross-reactivity.

🌿 Environmental & Ecological Impact

🐝 Bees / PollinatorsMODERATE
🐟 Fish / Aquatic LifeLOW
🐦 BirdsLOW
🐕 Mammals / PetsLOW
🦐 Aquatic InvertebratesMODERATE
💡 Systemic diamide. Lower bee risk than most insecticides. Some concern about chronic pollinator exposure through pollen.

❓ Frequently Asked Questions

Q: Is cyantraniliprole safe for pets?
Follow the product label. Keep pets out of treated areas until completely dried (2–4 hours for sprays). Once dry, treated surfaces pose minimal risk to dogs and cats.
Q: Can I use cyantraniliprole indoors?
Check the specific product label — formulations vary. Baits and dusts often have indoor labeling; concentrates and granulars are typically outdoor.
Q: How long does cyantraniliprole last after application?
Residual varies by formulation, surface type, weather, and UV exposure. Indoor applications last longer than outdoor. Check the product label for re-application intervals.
Q: What should I do if exposed?
Remove contaminated clothing, wash skin with soap and water. For eye contact, rinse 15–20 minutes. For ingestion or severe symptoms, call Poison Control (1-800-222-1222). Have the product label available.

📋 Safety Data Sheet (SDS)

📋

Cyantraniliprole — Safety Data Sheet

View the official SDS document for this product directly on the CDMS label database.

Cyantraniliprole Safety Data Sheet page 1
📄 Cyantraniliprole — Safety Data Sheet · View the complete SDS document above or download below
💡 Did you know? Cyantraniliprole was developed by DuPont (now FMC/Corteva) and first registered in 2013. It's part of the diamide class — the fastest-growing insecticide class in history, projected to be the world's largest-selling insecticide class by revenue.
🔮
Reviewed by Derek GiordanoContent reviewed by a licensed pest management professional. Last reviewed: April 2026.
📚 Sources: Texas A&M Fire Ant Project · EPA Safe Pest Control
Published: Jan 1, 2025 · Updated: Apr 7, 2026