The label is the law. Rates and restrictions below are taken from the product labels listed under Sources. Your product's own label governs; read it before you mix or apply. Mixing calculator · Disclaimer
- Active ingredient
- Cyazofamid
- Chemical class
- Cyano-imidazole; FRAC Group 21 QiI fungicides, which act at the Qi site of complex III in fungal respiration.[2][1]
- Mode of action
- FRAC Group 21: QiI fungicides (quinone inside inhibitors): cyano-imidazoles[2]
- Signal word
- Cyazofamid 400SC Turf and Ornamental Fungicide: Caution[1]
Not for do-it-yourself lawn care
The label lists residential and commercial lawns among its turf sites, but it plainly says application by homeowners to residential turf is prohibited. A lawn needing it would be treated by a professional.[1]
Group 21 rotation rules
FRAC places cyazofamid in Group 21 and assumes medium to high resistance risk, so resistance management is required. The label caps turf at two back-to-back cyazofamid sprays before switching to a different mode of action.[2][1]
Where it is used
Cyazofamid has limited systemic activity, so the label treats it as a protectant: apply before infection. Protection lasts 7 to 28 days depending on disease pressure.[1]
On newly seeded turf, apply 0.45 fl oz in 2 to 4 gallons per 1,000 sq ft right after seeding to guard against Pythium damping-off.[1]
For Pythium root dysfunction, spray every 21 to 28 days in fall and spring when mean daily soil temperature sits between 50 and 75 degrees F.[1]
Container drenches should wet the root zone with no more than 5% run-through, which is about 1 pint of solution per sq ft for 4-inch-deep media.[1]
Products and registrations
| Product | Registrant | EPA Reg. No. | Active % | Formulation | Signal word |
|---|---|---|---|---|---|
| Cyazofamid 400SC Turf and Ornamental Fungicide[1] | ISK Biosciences Corporation | 71512-13 | 34.5% | suspension concentrate | Caution |
Label rates
| Product | Use | Pests | Rate |
|---|---|---|---|
| Cyazofamid 400SC Turf and Ornamental Fungicide | Golf courses, sod and seed farms, athletic fields, residential and commercial lawns (professional use) | Pythium blight, Pythium damping-off, Pythium root dysfunction, Pythium root rot | 0.45–0.9 fl oz product per 1,000 sq ft[1] Mixed in 2 to 4 gallons of water per 1,000 sq ft, every 14 to 28 days depending on the disease. After root dysfunction and root rot sprays, irrigate with at least 1/8 inch of water. |
| Cyazofamid 400SC Turf and Ornamental Fungicide | Container and field-grown ornamentals in greenhouses, nurseries and landscapes | Pythium crown and root rots, damping-off | 1.5–3.0 fl oz product per 100 gallons of water[1] A drench or soil surface spray every 14 to 28 days, alternating with a fungicide from another group between cyazofamid treatments. |
| Cyazofamid 400SC Turf and Ornamental Fungicide | Container and field-grown ornamentals | Phytophthora crown and root rots, Phytophthora foliar blights | 3.0–6.0 fl oz product per 100 gallons of water[1] Use the shortest interval under severe pressure. Foliar sprays are limited to 6 fl oz per acre each and 4 sprays a year. |
| Cyazofamid 400SC Turf and Ornamental Fungicide | Ornamental plants | Downy mildews | 2.1–3.5 fl oz product per 100 gallons of water[1] On a 14- to 21-day schedule, in 50 to 100 gallons per acre to wet foliage to runoff. No more than two foliar sprays in a row. |
Safety and environmental hazards
People
Signal word CAUTION: harmful if absorbed through skin. Avoid breathing the spray mist, and wear long sleeves, long pants, socks, shoes and waterproof chemical-resistant gloves.[1]
Pets
On lawns, landscapes and sports fields, the label says to keep children, pets and unprotected people out of the treated area until sprays have dried.[1]
Bees and pollinators
The label has no bee or pollinator warning.[1]
Fish and water
Toxic to aquatic invertebrates. Don't apply directly to water, and remember that drift and runoff may harm aquatic life in nearby water.[1]
Common questions
- Does cyazofamid control brown patch or dollar spot?
- No. Its turf uses are all Pythium diseases. The ornamental uses add Phytophthora and downy mildews, which are also water molds.[1]
- How much cyazofamid can go on turf in a year?
- No more than 2.7 fl oz of product per 1,000 sq ft per year: three sprays at 0.9 fl oz, or up to six at 0.45 fl oz.[1]
- What FRAC group is cyazofamid?
- Group 21, the QiI fungicides that act at the Qi site of the cytochrome bc1 complex.[2]
Sources
- U.S. EPA Pesticide Product Label System, “Cyazofamid 400SC Turf and Ornamental Fungicide label, EPA Reg. No. 71512-13 (EPA-stamped, Sept. 5, 2024).” www3.epa.gov/pesticides/chem_search/ppls/071512-00013-20240905.pdf (accessed 2026-10-06)
- Fungicide Resistance Action Committee, “FRAC Code List 2025.” www.frac.info/media/ljsi3qrv/frac-code-list-2025.pdf (accessed 2026-10-06)