The label is the law. Rates and restrictions below are taken from the product labels listed under Sources. Your product's own label governs; read it before you mix or apply. Mixing calculator · Disclaimer
- Active ingredient
- Difenoconazole (CAS 119446-68-3)
- Chemical class
- Triazole; FRAC Group 3 DMI fungicides, which inhibit the C14-demethylase step of sterol biosynthesis.[2]
- Mode of action
- FRAC Group 3: DMI fungicides: demethylation inhibitors in sterol biosynthesis (triazoles)[2]
- Signal word
- Inspire Fungicide: Warning[1]
Homeowner rose use on a farm label
Inspire's ornamental directions cover established landscape plants at parks, golf courses and homes, and name non-professional homeowner applicators. Roses get 4.8 mL per gallon, with no more than four full-rate sprays a year.[1]
That ornamental use excludes plants grown for sale in commercial greenhouses or nurseries, and is not for use in California.[1]
Rotating Group 3 fungicides
FRAC lists difenoconazole among the DMI triazoles, and generally assumes cross-resistance between DMIs active against the same fungus. The label says to rotate Inspire with other groups and stop after two sprays in a row.[2][1]
Where it is used
Thorough coverage matters. Mix only as much as you will spray, and avoid overlapping passes, which the label says can injure the crop.[1]
For apple scab, start at a quarter- to half-inch green tip and continue through petal fall. Adding a protectant fungicide from bloom on improves fruit scab control.[1]
On labrusca grapes such as Concord and other non-vinifera hybrids, the label warns Inspire can cause leaf burn, whether used alone or mixed with adjuvants or foliar fertilizers that increase uptake.[1]
Don't inject it full strength into irrigation lines; dilute at least 10 parts water to 1 part Inspire, because it attacks many seal materials.[1]
Products and registrations
| Product | Registrant | EPA Reg. No. | Active % | Formulation | Signal word |
|---|---|---|---|---|---|
| Inspire Fungicide[1] | Syngenta Crop Protection, LLC | 100-1262 | 23.2% | emulsifiable concentrate | Warning |
Label rates
| Product | Use | Pests | Rate |
|---|---|---|---|
| Inspire Fungicide | Tomato, pepper, eggplant, tomatillo and other fruiting vegetables | Early blight, black mold, gray leaf spot, powdery mildew, Septoria leaf spot, target spot, anthracnose, leaf mold | 4–7 fl oz product per acre[1] Spray every 7 to 14 days and make no more than two Inspire sprays in a row before switching groups. It can go on up to the day of harvest. |
| Inspire Fungicide | Apple, crabapple, pear, quince and other pome fruit | Apple scab, cedar-apple rust, quince rust, powdery mildew, Alternaria blotch, sooty blotch, flyspeck | 4 fl oz product per acre[1] Every 7 to 10 days from green tip for scab. Limit is 20 fl oz per acre a year, and the last spray must be at least 14 days before harvest. |
| Inspire Fungicide | Roses, carnation, gladiolus and iris in established landscapes | Black spot, rust, powdery mildew | 1.4–4.8 mL product per gallon of water (treats 1,000 sq ft)[1] Roses, carnations and gladiolus take 4.8 mL per gallon; iris rust takes 1.4 to 2.7 mL. Measure with the syringe supplied with the product. |
Safety and environmental hazards
People
Signal word WARNING: causes substantial but temporary eye injury and is harmful if swallowed. Handlers wear protective eyewear, chemical-resistant gloves, long sleeves, long pants, socks and shoes.[1]
Pets
In landscapes and other non-farm sites, keep unprotected people out of treated areas until the spray has dried. The emergency hotline on the label covers animals as well as humans.[1]
Bees and pollinators
The Inspire label has no bee or pollinator hazard statement.[1]
Fish and water
Toxic to fish, mammals and aquatic invertebrates. The label warns it can run off for several months after application, so avoid spraying when rain is expected within 48 hours.[1]
Common questions
- Can I spray difenoconazole on tomatoes right before picking?
- Yes, on the Inspire label. Fruiting vegetables have a 0-day pre-harvest interval, with a cap of 28 fl oz per acre a year.[1]
- How much Inspire per gallon for roses?
- 4.8 mL per gallon of water, with that gallon covering 1,000 sq ft. Spray every 7 to 14 days starting at the first sign of black spot, rust or mildew.[1]
- Is difenoconazole the same kind of fungicide as tebuconazole and propiconazole?
- Yes. FRAC places all three in Group 3, the DMI triazoles.[2]
Sources
- U.S. EPA Pesticide Product Label System, “Inspire Fungicide label, EPA Reg. No. 100-1262 (EPA-stamped, Mar. 20, 2020).” www3.epa.gov/pesticides/chem_search/ppls/000100-01262-20200320.pdf (accessed 2026-10-06)
- Fungicide Resistance Action Committee, “FRAC Code List 2025.” www.frac.info/media/ljsi3qrv/frac-code-list-2025.pdf (accessed 2026-10-06)