The label is the law. Rates and restrictions below are taken from the product labels listed under Sources. Your product's own label governs; read it before you mix or apply. Mixing calculator · Disclaimer
- Active ingredient
- Fluoxastrobin
- Chemical class
- Dihydro-dioxazine strobilurin; FRAC Group 11 QoI fungicides (quinone outside inhibitors at complex III).[2]
- Mode of action
- FRAC Group 11: QoI fungicides (quinone outside inhibitors): dihydro-dioxazines[2]
- Signal word
- F4291-1 SC Fungicide (sold as Fame SC Fungicide and Skyward Fungicide): Caution[1]
Strobilurin resistance
FRAC classes fluoxastrobin with azoxystrobin, pyraclostrobin and trifloxystrobin in Group 11, and notes cross-resistance among all Group 11 fungicides for G143A mutants. FRAC rates the group high risk.[2]
The label says to rotate with other fungicide groups, or tank-mix with them. For severe dollar spot, anthracnose, gray leaf spot or heavy Pythium pressure, it calls for adding a partner fungicide.[1]
New York restrictions
The label makes this product a restricted use pesticide in New York State and bans its sale and use in Nassau and Suffolk Counties. In New York it also can't go within 100 feet of a coastal marsh.[1]
Where it is used
The label says fluoxastrobin moves into green tissue through translaminar and xylem movement, is rainfast in as little as 15 minutes, and is also taken up by roots.[1]
For root and crown diseases, use enough spray water to carry it into the crown and upper root zone, or irrigate with 1/8 to 1/2 inch of water afterward.[1]
For spring dead spot on bermudagrass, make 1 or 2 applications at 0.4 fl oz about a month before the grass goes dormant.[1]
Do not use it on leatherleaf fern or other ferns grown under natural or artificial shade.[1]
Products and registrations
| Product | Registrant | EPA Reg. No. | Active % | Formulation | Signal word |
|---|---|---|---|---|---|
| F4291-1 SC Fungicide (sold as Fame SC Fungicide and Skyward Fungicide)[1] | Environmental Science U.S., LLC | 101563-370 | 40.3% | suspension concentrate | Caution |
Label rates
| Product | Use | Pests | Rate |
|---|---|---|---|
| F4291-1 SC Fungicide (sold as Fame SC Fungicide and Skyward Fungicide) | Lawns, golf courses, sod farms, athletic fields and landscape turf | Brown patch, large patch, zoysia patch, dollar spot, gray leaf spot, leaf spot, red thread, rust, Pythium blight and root rot, summer patch, take-all patch, spring dead spot, snow molds | 0.1–0.4 fl oz product per 1,000 sq ft[1] Brown patch and large patch start at 0.1 fl oz; most other diseases use 0.2 to 0.4 fl oz. Intervals run 7 to 28 days. No more than 16 fl oz per acre per spray and 4 sprays a season. |
| F4291-1 SC Fungicide (sold as Fame SC Fungicide and Skyward Fungicide) | Ornamentals in greenhouses, nurseries, interiorscapes and residential or commercial landscapes | Leaf spots and blights, powdery mildews, rusts, downy mildew, anthracnose, Botrytis blight | 1–8 fl oz product per 100 gallons of water[1] Most foliar diseases take 1 to 4 fl oz; anthracnose leaf spot and Botrytis blight take 4 to 8 fl oz. Spray to the point of drip, no more than 4 times a year. |
Safety and environmental hazards
People
Signal word CAUTION: prolonged or frequently repeated skin contact may cause allergic reactions in some people. Handlers wear long sleeves, long pants, shoes, socks and waterproof gloves.[1]
Pets
For lawn and landscape uses, the label says to keep children and pets out of the treated area until the spray has dried.[1]
Bees and pollinators
There is no bee or pollinator statement on this label.[1]
Fish and water
Toxic to fish and aquatic invertebrates, and the active ingredient can persist for several months or longer. Keep spray away from water and sensitive areas that drift could reach.[1]
Common questions
- How much fluoxastrobin per 1,000 sq ft for brown patch?
- 0.1 to 0.4 fl oz of product every 14 to 28 days. For a curative spring spray, the label calls for the 16 fl oz per acre rate on a 14-day interval.[1]
- Is fluoxastrobin a strobilurin like azoxystrobin?
- Yes. FRAC lists both as Group 11 QoI fungicides and reports cross-resistance among Group 11 members, so switching between them is not a rotation.[2]
- How often can I apply Fame SC to a lawn?
- No more than 4 applications per season, and no more than 68 fl oz per acre per year.[1]
Sources
- U.S. EPA Pesticide Product Label System, “F4291-1 SC Fungicide (Fame SC) label, EPA Reg. No. 101563-370 (EPA-stamped, June 25, 2018).” www3.epa.gov/pesticides/chem_search/ppls/000279-03634-20180625.pdf (accessed 2026-10-06). EPA's site files this label under the product's earlier registration number, 279-3634; Fame SC and Skyward are its alternate brand names.
- Fungicide Resistance Action Committee, “FRAC Code List 2025.” www.frac.info/media/ljsi3qrv/frac-code-list-2025.pdf (accessed 2026-10-06)