Sulfoxaflor is a next-generation insecticide that targets the same receptor as neonicotinoids (nicotinic acetylcholine receptor) but with a different binding mechanism. It's effective against many neonicotinoid-resistant pest populations, particularly sap-feeding insects like aphids and whiteflies.
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Classification
Sulfoximine Insecticide
Signal Word
Caution
Mode of Action
Nicotinic acetylcholine receptor agonist (sulfoximine subclass) — same target as neonics but different binding site
Aphids (excellent, including neonicotinoid-resistant strains), whiteflies, plant bugs (Lygus, tarnished plant bug), brown marmorated stink bug, Asian citrus psyllid, leafhoppers. Primarily targets sucking insects. Less effective on chewing insects compared to diamides.
🏷️ Products & Brand Names
Transform WG (Corteva — professional/agricultural), Closer SC (Corteva), Sequoia (professional ornamental). Currently limited to professional and agricultural markets — no major homeowner brands yet.
⚠️ Safety & Precautions
Low to moderate mammalian toxicity. EPA Reduced Risk designation initially, though pollinator concerns led to modified labeling.
⚠️ Pollinator controversy: Sulfoxaflor's registration has been legally challenged due to bee toxicity concerns. Current labels prohibit application during bloom on bee-attractive crops. The legal status has fluctuated — check current label restrictions before use.
Follow all label directions regarding application timing relative to bloom periods. Do not apply when bees are foraging.
Example
0.5 oz
per gallon
⚗️ Mixing Calculator
Enter your sprayer size and target rate — get the exact amount to pour. Backpack, hand sprayer, hose-end, or skid unit.
The neonicotinoid resistance story: Sulfoxaflor was developed specifically to combat neonicotinoid-resistant insect populations. While it targets the same receptor (nAChR), it binds at a different site — meaning insects that have evolved resistance to imidacloprid or thiamethoxam may still be susceptible to sulfoxaflor.
Speed: Sulfoxaflor acts very quickly — affected insects stop feeding within hours and die within 24-48 hours. This rapid feeding cessation is important for virus-vectoring insects like aphids and psyllids.
🐛 Pests This Treats — Learn More
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💡 Sulfoximine insecticide. Highly toxic to bees — EPA restricts application during bloom. Low vertebrate toxicity.
❓ Frequently Asked Questions
Q: Is sulfoxaflor safe for pets?
Follow the product label. Keep pets out of treated areas until completely dried (2–4 hours for sprays). Once dry, treated surfaces pose minimal risk to dogs and cats.
Q: Can I use sulfoxaflor indoors?
Check the specific product label — formulations vary. Baits and dusts often have indoor labeling; concentrates and granulars are typically outdoor.
Q: How long does sulfoxaflor last after application?
Residual varies by formulation, surface type, weather, and UV exposure. Indoor applications last longer than outdoor. Check the product label for re-application intervals.
Q: What should I do if exposed?
Remove contaminated clothing, wash skin with soap and water. For eye contact, rinse 15–20 minutes. For ingestion or severe symptoms, call Poison Control (1-800-222-1222). Have the product label available.
📋 Safety Data Sheet (SDS)
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Sulfoxaflor — Safety Data Sheet
View the official SDS document for this product directly on the CDMS label database.
💡 Did you know? Sulfoxaflor was the first member of the sulfoximine insecticide class, registered in 2013. Its development was driven by the growing problem of neonicotinoid resistance in key agricultural pests, particularly cotton aphids and soybean aphids.
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Reviewed by Derek GiordanoContent reviewed by a licensed pest management professional. Last reviewed: April 2026.
