Neonicotinoid mechanism of action diagram

How neonicotinoid works — illustrated mechanism of action · PestControlBasics.com

OTC/DIY CAUTION

Clothianidin — Arena, Grub-Ex Season Long

Active ingredient: clothianidin  ·  Residual: Up to 12 months (soil)

⚠️ Don't buy duplicates. All brands listed contain the same active ingredient. Buying two different brands is buying the same pesticide twice.
⚖️ Educational use only. Always read and follow the full product label — the label is the law under FIFRA. Full disclaimer → | ⚗️ Mixing Calculator →

🏷️ Brand Names — Same Active Ingredient

Arena 50 WDG — OHP — professional turf/ornamental
Celero — Bayer CropScience — agricultural seed treatment
Grub-Ex Season Long — Scotts — consumer lawn
Belay — Valent — ag foliar/soil

🎯 What It Kills

✓ White Grubs✓ Billbugs✓ Aphids✓ Whiteflies✓ Leafhoppers✓ Japanese Beetle larvae

⚙️ How It Works

Clothianidin is a neonicotinoid systemic with long soil residual — primary active ingredient in professional grub prevention programs. Works through systemic plant uptake and soil contact.

⚗️ Mixing & Application

Arena 50 WDG: 0.1–0.2 oz per 1,000 sq ft for grub prevention. Apply June–July, water in immediately. Consumer Grub-Ex: apply per label.
Example
0.5 oz
per gallon
⚗️ Mixing Calculator
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⚠️ Safety

  • ⚠ Highly toxic to bees — one of the most scrutinized neonicotinoids for pollinator impacts
  • ⚠ Soil residual up to 12 months
  • ⚠ Do not apply to impervious surfaces near drains

🐛 Pests This Treats — Learn More

Click any pest to view its full identification guide, biology, and treatment options.

🐛 Aphid → 🐛 Billbugs → 🐛 Flies → 🐛 Grubs → 🐛 Japanese Beetle → 🐛 Leafhopper → 🐛 Scales → 🐛 Ticks → 🐛 Whiteflies →

🌿 Environmental & Ecological Impact

🐝 Bees / PollinatorsVERY HIGH
🐟 Fish / Aquatic LifeLOW
🐦 BirdsLOW
🐕 Mammals / PetsLOW
🦐 Aquatic InvertebratesHIGH
💡 Extremely toxic to bees. Persistent in soil. Linked to pollinator decline.

⏱️ Residual & Re-entry Timeline

🔹
Apply
Follow label mixing and application rates
🔸
Re-entry: 2–4 hours (until dry)
Keep people and pets out of treated area
🟢
Effective period: Up to 12 months (soil)
Active residual — killing or repelling target pests
🔄
Reapply
Re-treat when pest activity returns or residual expires

❓ Frequently Asked Questions

Q: Is clothianidin safe for pets?
Follow the product label. Keep pets out of treated areas until completely dried (2–4 hours for sprays). Once dry, treated surfaces pose minimal risk to dogs and cats.
Q: Can I use clothianidin indoors?
Check the specific product label — formulations vary. Baits and dusts often have indoor labeling; concentrates and granulars are typically outdoor.
Q: How long does clothianidin last after application?
Residual varies by formulation, surface type, weather, and UV exposure. Indoor applications last longer than outdoor. Check the product label for re-application intervals.
Q: What should I do if exposed?
Remove contaminated clothing, wash skin with soap and water. For eye contact, rinse 15–20 minutes. For ingestion or severe symptoms, call Poison Control (1-800-222-1222). Have the product label available.

📋 Safety Data Sheet (SDS)

📋

Arena 50 WDG — Safety Data Sheet

View the official SDS document for this product directly on the CDMS label database.

Arena 50 WDG Safety Data Sheet page 1
📄 Arena 50 WDG — Safety Data Sheet · View the complete SDS document above or download below
📚 Sources: EPA Pesticide Labels · NPIC Pesticide Info
Published: Jan 1, 2025 · Updated: Apr 7, 2026
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Reviewed by Derek GiordanoContent reviewed by a licensed pest management professional and cross-referenced against EPA, university extension, and manufacturer technical data. Last reviewed: April 2026.