The label is the law. Read your product's label before you mix or apply; the rates here come from the labels listed under Sources.
- Active ingredient
- Flupyradifurone (CAS 951659-40-8)
- Chemical class
- Butenolide; IRAC Group 4D nicotinic acetylcholine receptor competitive modulators.[2]
- Mode of action
- IRAC Group 4D: Nicotinic acetylcholine receptor (nAChR) competitive modulators: butenolides[2]
- Signal word
- Sivanto 200 SL: Caution[1]
Group 4D and rotation
IRAC places butenolides in Group 4D, a separate subgroup from neonicotinoids (4A) and sulfoximines (4C), though all act on the nicotinic acetylcholine receptor.[2]
Where it is used
It can be sprayed on foliage by ground or air, or applied to soil through drip chemigation, in-furrow, shank injection or drench where the crop directions allow.[1]
Use the lower rate for light infestations and the higher rate for heavy ones.[1]
Don't tank-mix it with azole (FRAC Group 3) fungicides during bloom.[1]
Products and registrations
| Product | Registrant | EPA Reg. No. | Active % | Formulation | Signal word |
|---|---|---|---|---|---|
| Sivanto 200 SL[1] | Bayer CropScience LP | 264-1141 | 17.09% | soluble liquid | Caution |
Label rates
| Product | Use | Pests | Rate |
|---|---|---|---|
| Sivanto 200 SL | Broccoli, Brussels sprouts, cabbage, cauliflower and kohlrabi (one of many labeled crops) | Aphids, green peach aphid, leafhoppers, whiteflies | 7.0–14.0 fl oz product per acre[1] 7 to 14 fl oz per acre for aphids and leafhoppers; 10.5 to 14 fl oz for green peach aphid and whiteflies. 1-day harvest interval, 7 days between applications, and no more than 28 fl oz per acre per crop season. |
Safety and environmental hazards
People
Signal word CAUTION. Applied under the Worker Protection Standard; don't let spray contact workers or other people, directly or through drift.[1]
Pets
It is an agricultural product with CAUTION labeling, not a home-use product.[1]
Bees and pollinators
Highly toxic to adult alfalfa leafcutting bees by direct contact, so it isn't applied while managed leafcutting bees forage. It is toxic to adult bees orally in lab studies but not to honey bees or bumble bees by contact, and field studies showed no effects on honey bee colony development.[1]
Fish and water
Toxic to aquatic invertebrates; drift and runoff may harm aquatic life in nearby water.[1]
Common questions
- Is flupyradifurone safe for honey bees?
- The label says it is not toxic to honey bees or bumble bees through contact and field studies showed no effects on honey bee colony development, but it is toxic to adult bees orally in lab studies and highly toxic to alfalfa leafcutting bees.[1]
- Is Sivanto a neonicotinoid?
- Not by IRAC's classification: flupyradifurone is a butenolide in Group 4D, while neonicotinoids are Group 4A.[2]
- How soon can treated broccoli or cabbage be harvested?
- One day after application, per the label's brassica directions.[1]
Sources
- U.S. EPA Pesticide Product Label System, “Sivanto 200 SL (supplemental label) label, EPA Reg. No. 264-1141 (EPA-stamped, June 3, 2021).” www3.epa.gov/pesticides/chem_search/ppls/000264-01141-20210603.pdf (accessed 2026-10-06)
- Insecticide Resistance Action Committee, “IRAC Mode of Action Classification Scheme, Version 11.5 (Feb. 2026).” irac-online.org/documents/moa-classification/ (accessed 2026-10-06)