The label is the law. Read your product's label before you mix or apply; the rates here come from the labels listed under Sources.
- Active ingredient
- Cyantraniliprole (CAS 736994-63-1)
- Chemical class
- Diamide; IRAC Group 28 ryanodine receptor modulators.[2]
- Mode of action
- IRAC Group 28: Ryanodine receptor modulators: diamides[2]
- Signal word
- Mainspring GNL Insecticide: none required[1]
Diamides in rotation
IRAC Group 28 diamides act on insect ryanodine receptors in muscle, a different target from neonicotinoids (Group 4) and pyrethroids (Group 3), which makes them a rotation option for thrips and whiteflies.[2][1]
Where it is used
As a foliar spray it moves translaminarly and systemically within leaves; as a soil drench it is taken up by roots and moves upward, faster in herbaceous plants than in trees and shrubs.[1]
Make soil applications before an expected infestation so it has time to move through the plant.[1]
It may be applied as a foliar spray, soil broadcast spray, drench, soil injection or through chemigation.[1]
Products and registrations
| Product | Registrant | EPA Reg. No. | Active % | Formulation | Signal word |
|---|---|---|---|---|---|
| Mainspring GNL Insecticide[1] | Syngenta Crop Protection, LLC | 100-1543 | 18.66% | flowable concentrate | none |
Label rates
| Product | Use | Pests | Rate |
|---|---|---|---|
| Mainspring GNL Insecticide | Ornamentals, trees, shrubs, ground covers, palms and non-bearing fruit and nut trees | Aphids, lace bugs, leaf-feeding beetles (Japanese beetle adults, viburnum leaf beetle), caterpillars, leafminers, soft scales, thrips, whiteflies | 2–16 fl oz product per 100 gallons of water[1] 4 to 8 fl oz per 100 gallons for aphids, 2 to 8 fl oz for the other listed pests, and 16 fl oz for maximum residual control; reapply on 7- to 14-day intervals. No more than 32 fl oz per acre per year. |
Safety and environmental hazards
People
The product carries no signal word. Workers stay out of treated greenhouse and nursery areas for a 4-hour restricted-entry interval after sprays.[1]
Pets
Landscape applications are professional uses; follow the label's directions to keep spray off people and nontarget areas.[1]
Bees and pollinators
Highly toxic to bees exposed to direct treatment or residues on blooming plants; don't apply or let it drift onto blooming crops or weeds while bees are foraging.[1]
Fish and water
Toxic to aquatic invertebrates, and classified as having a high potential to reach surface water through runoff, especially on poorly draining soils.[1]
Common questions
- Is cyantraniliprole systemic?
- Yes. The label says it has contact and systemic activity, moving within leaves after a foliar spray and upward through the plant after a soil drench.[1]
- Is cyantraniliprole harmful to bees?
- The label says it is highly toxic to bees exposed to direct treatment or residues on blooming plants.[1]
- How much Mainspring GNL per gallon?
- About 0.6 to 2.4 mL per gallon for most listed pests, 1.2 to 2.4 mL for aphids, and up to 4.7 mL for maximum residual control.[1]
Sources
- U.S. EPA Pesticide Product Label System, “Mainspring GNL Insecticide label, EPA Reg. No. 100-1543 (EPA-stamped, Sept. 27, 2023).” www3.epa.gov/pesticides/chem_search/ppls/000100-01543-20230927.pdf (accessed 2026-10-06)
- Insecticide Resistance Action Committee, “IRAC Mode of Action Classification Scheme, Version 11.5 (Feb. 2026).” irac-online.org/documents/moa-classification/ (accessed 2026-10-06)